The Effect of Trichosanthes Kirilowii Maximowicz Extract and Trichosanthes Kirilowii Maximowicz Cheonghyeol Plus on Anti-Inflammatory Factor Expression in Human Umbilical Vein Endothelial Cells (HUVECs)

Objective: To examine the effects of Trichosanthes kirilowii Maximowicz extract (TE) and Maxi mowicz Cheonghyeol Plus Phellinus linteus plus (TCP) on anti-inflammatory factor expression in human umbilical vein endothelial cells (HUVECs).Methods: HUVECs were activated with TNF-α then treated TE TCP. The levels measured for intracellular genes (KLF2, eNOS, MCP-1, ICAM-1, VCAM-1), proteins VCAM-1, ERK, JNK, p38), extracellular biomarkers (ICAM-1, MCP-1).Results:1. TCP at concentrations 100 μg/mL or greater significantly increased KLF2 eNOS decreased MCP-1 compared to control group.</br>2. KLF2, group, reduced p38 proteins. However, JNK protein phosphorylation showed no significant change group.</br>3. more production VCAM-1 group.</br>4. a concentration did not cause any proteins, biomarker amount group. Other genes, same trend as observed exposure.Conclusion: This study experimentally confirmed that could be effective preventing inhibiting various inflammatory vascular diseases due their effects.